Calculate a maintenance dose from clearance, target average steady-state concentration, dosing interval, bioavailability and salt factor.
About this tool
Maintenance dose from clearance, target concentration and dosing interval.
How to use Maintenance Dose Calculator
- Enter clearance in L/h or mL/min.
- Enter the target concentration and dosing interval.
- Add bioavailability and salt factor, then read the dose per interval.
Worked example
A clearance of 4.5 L/h and a target of 10 mg/L need 540 mg every 12 hours (45 mg/h).
What does steady state mean?
The level at which the amount given per interval equals the amount eliminated, reached after about 4–5 half-lives.
Does this give peak and trough levels?
No. It targets the average level. Peaks and troughs also depend on the half-life and the dosing interval.
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