Maintenance Dose Calculator
Maintenance dose from clearance, target concentration and dosing interval.
Enter your values to see the result.
Maintenance dose = CL × Css,avg × τ ÷ (F × S). Peak and trough levels depend on the half-life as well, so monitor drug levels where recommended. For education and clinical decision support only. Results do not replace professional judgment, local protocols or the product information, so always verify doses and values before acting on them.
Continue your work
- Loading Dose Calculator — Reach the target level quickly.
- Drug Half-Life Calculator — Estimate time to steady state.
Share this tool
Found it useful? Send it to a friend or teammate.
Rate this tool
0.0
0 ratings
- 5 stars 0
- 4 stars 0
- 3 stars 0
- 2 stars 0
- 1 star 0
Clear instructions
Find steps, examples and limitations below.
Use online
Open the tool in a supported web browser.
Free to use
No sign-up required. Tool-specific limits may apply.
How to use the Maintenance Dose Calculator
Maintenance dose from clearance, target concentration and dosing interval.
- 1 Enter clearance in L/h or mL/min.
- 2 Enter the target concentration and dosing interval.
- 3 Add bioavailability and salt factor, then read the dose per interval.
Example and practical tips
A clearance of 4.5 L/h and a target of 10 mg/L need 540 mg every 12 hours (45 mg/h).
Frequently asked questions
What does steady state mean?
The level at which the amount given per interval equals the amount eliminated, reached after about 4–5 half-lives.
Does this give peak and trough levels?
No. It targets the average level. Peaks and troughs also depend on the half-life and the dosing interval.
Report an issue
Something broken or not quite right? Tell us and we will look into it.