Maintenance Dose Calculator
Maintenance dose from clearance, target concentration and dosing interval.
Enter your values to see the result.
Maintenance dose = CL × Css,avg × τ ÷ (F × S). Peak and trough levels depend on the half-life as well, so monitor drug levels where recommended. For education and clinical decision support only. Results do not replace professional judgment, local protocols or the product information, so always verify doses and values before acting on them.
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Read the privacy policyHow this calculation works
Understand the method, inputs and limits behind your result.
- Formula
- Maintenance dose per interval = target concentration × clearance × dosing interval / bioavailability fraction. Dose rate = target concentration × clearance / bioavailability.
- Variables
- Clearance
- Unit: L/h, mL/min
- Target average steady-state concentration
- Dosing interval (τ)
- Bioavailability (F)
- Salt factor (S)
- Units
- Target average steady-state concentration: mg/L
- Dosing interval (τ): h
- Bioavailability (F): %
- Salt factor (S): %
- Example
- A clearance of 4.5 L/h and a target of 10 mg/L need 540 mg every 12 hours (45 mg/h).
- Assumptions
- Maintenance dose = CL × Css,avg × τ ÷ (F × S). Peak and trough levels depend on the half-life as well, so monitor drug levels where recommended. For education and clinical decision support only. Results do not replace professional judgment, local protocols or the product information, so always verify doses and values before acting on them.
- Source
- ToolzHive calculation guide and calculator implementation. External reference verification is pending.
- Last reviewed
- Review date not yet recorded.
Methodology & References
The method depends on the selected model and input options. Review the assumptions and references above before interpreting the result.
- Enter clearance in L/h or mL/min.
- Enter the target concentration and dosing interval.
- Add bioavailability and salt factor, then read the dose per interval.
Interpretation and limitations
- What does steady state mean? The level at which the amount given per interval equals the amount eliminated, reached after about 4–5 half-lives.
- Does this give peak and trough levels? No. It targets the average level. Peaks and troughs also depend on the half-life and the dosing interval.
References
External reference verification is pending. The formula and examples describe the current ToolzHive implementation.
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Clear instructions
Find steps, examples and limitations below.
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How to use the Maintenance Dose Calculator
Maintenance dose from clearance, target concentration and dosing interval.
- 1 Enter clearance in L/h or mL/min.
- 2 Enter the target concentration and dosing interval.
- 3 Add bioavailability and salt factor, then read the dose per interval.
Example and practical tips
A clearance of 4.5 L/h and a target of 10 mg/L need 540 mg every 12 hours (45 mg/h).
Frequently asked questions
What does steady state mean?
The level at which the amount given per interval equals the amount eliminated, reached after about 4–5 half-lives.
Does this give peak and trough levels?
No. It targets the average level. Peaks and troughs also depend on the half-life and the dosing interval.
Practical guides
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How to Use Maintenance Dose Calculator
Calculate a maintenance dose from clearance, target average steady-state concentration, dosing interval, bioavailability and salt factor.
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