Pharmacokinetic Calculator
Non-compartmental Cmax, Tmax, AUC, half-life, clearance and volume.
Enter your values to see the result.
Non-compartmental analysis: λz comes from a log-linear regression of the last points, AUC₀–∞ = AUC₀–t + C_last ÷ λz, CL = dose ÷ AUC₀–∞ and Vz = CL ÷ λz. For oral dosing CL and V are apparent values divided by bioavailability (CL/F, Vz/F).
Continue your work
- Drug Half-Life Calculator — Quick half-life from two levels.
- Loading Dose Calculator — Use the volume to plan a loading dose.
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Clear instructions
Find steps, examples and limitations below.
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How to use the Pharmacokinetic Calculator
Non-compartmental Cmax, Tmax, AUC, half-life, clearance and volume.
- 1 Enter the dose and route, then paste time, concentration pairs.
- 2 Choose how many terminal points to use and the AUC method.
- 3 Read Cmax, Tmax, AUC, half-life, clearance and volume.
Example and practical tips
A 500 mg oral dose peaking at 9.4 mg/L at 2 h has a terminal half-life of 4.2 h and an AUC₀–∞ of 72.5 mg·h/L.
Frequently asked questions
What is the linear-up/log-down method?
It uses straight lines while levels rise and exponential curves while they fall, which is more accurate for elimination phases.
Why are clearance and volume “apparent” for oral doses?
Without IV data the bioavailability F is unknown, so the results are CL/F and Vz/F.
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